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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1051 | Retinoic acid | Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin | Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy |
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat... | |||
T21497 | 9-cis-Retinoic Acid | Alitretinoin | Apoptosis |
9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can... | |||
T77599 | Methyl retinoate | Retinoic acid, methyl ester | Others |
Methyl retinoate (Retinoic acid, methyl ester) induces aseptic inflammation at the site of administration in in vivo experiments, which causes an increase in the number of leukocytes in the blood and a decrease in the le... | |||
T37916 | 5,6-epoxy-13-cis Retinoic Acid | ||
5,6-epoxy-13-cis Retinoic Acid is a metabolite of 13-cis retinoic acid. | |||
T36382 | All-trans-5,6-epoxy Retinoic Acid | ||
all-trans-5,6-epoxy Retinoic Acid can be used in related research in the field of life sciences. Its product number is T36382 and CAS number is 13100-69-1. | |||
T67921 | Retinoic acid-d5 | all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 | Retinoid Receptor |
Retinoic acid-d5 (Vitamin A acid-d5) is the deuterium-labeled form of Retinoic acid. Retinoic acid is a natural RAR receptor agonist with an IC50 of 14 nM for RARα/β/γ and a Kd of 17 nM for PPARβ/δ. Retinoic acid, a meta... | |||
T1611 | Isotretinoin | 13-cis-Retinoic acid | Retinoid Receptor , Endogenous Metabolite , Autophagy |
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturall... | |||
T3203 | Methyl 13-cis-4-Oxoretinoate | 13-cis-4-Oxo-retinoic acid Methyl Ester,4-Keto 13-cis-Retinoic Acid Methyl Ester | Others |
Methyl 13-cis-4-Oxoretinoate (13-cis-4-Oxo-retinoic acid Methyl Ester) is a retinoic acid metabolite in neuroblastoma. | |||
T7408 | All-trans-4-Oxoretinoic acid | all-trans 4-Keto Retinoic Acid | Endogenous Metabolite |
all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) is an active metabolite of vitamin A. | |||
T3955 | AR7 | Retinoid Receptor | |
AR7 is a retinoic acid receptor α (RARα) antagonist. | |||
TN6735 | Bigelovin | Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR | |
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote... | |||
T22843 | HX 531 | Retinoid Receptor | |
RXR antagonist | |||
T15811 | LY2955303 | Others , Retinoid Receptor | |
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM). | |||
TQ0097 | AGN 193109 | Retinoid Receptor , Autophagy | |
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ). | |||
T17209 | UVI 3003 | Retinoid Receptor , Autophagy | |
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively). | |||
T5341 | WYC-209 | WYC209 | Apoptosis , Retinoid Receptor , Autophagy |
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR). | |||
T1330 | Acitretin | Ro 10-1670,Etretin | Apoptosis , Retinoid Receptor , Autophagy |
Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. | |||
T23384 | SR 11302 | DNA/RNA Synthesis | |
SR 11302 is an inhibitor of activator protein-1 (AP-1). | |||
T16832 | S18-000003 | ROR | |
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. | |||
T7370 | Talarozole | R115866 | Others , P450 , Retinoid Receptor , Autophagy |
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of... |